Case Report: Challenges in immunotherapy for the elderly: a case of refractory ICI-induced AIHA and thrombocytopenia in advanced gastric cancer
This case underscores the diagnostic complexity and therapeutic challenges associated with immune checkpoint inhibitor induced autoimmune hemolytic anemia in elderly patients, particularly those experiencing immunosenescence and possessing limited hematopoietic reserve. The mechanisms underlying this phenomenon remain poorly understood, highlighting the urgent need for mechanistic investigations, individualized immunotherapeutic strategies, and vigilant hematologic monitoring in vulnerable populations.
Authors
- Yandong Bian
- Kun Wu (ORCID: https://orcid.org/0000-0002-3075-8272)
- Guohua Yu (ORCID: https://orcid.org/0000-0002-3260-3178)
- Linlin Ji (ORCID: https://orcid.org/0000-0002-7949-7034)
- Mingxin Yu (ORCID: https://orcid.org/0000-0002-8480-7666)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-9861-4681)
- Junying Zhang (ORCID: https://orcid.org/0000-0002-4860-8774)
- Yanhong Ding
- Shuzhen Liu (ORCID: https://orcid.org/0000-0002-0602-3217)
- Xin Shen (ORCID: https://orcid.org/0009-0004-1907-0620)
- Yuhui Nie
- Rongxuan Cao
- Yanfang Gao
- Yang Liu (ORCID: https://orcid.org/0000-0002-7240-1546)
Institutions
- Weifang Medical University (CN)
- Weifang People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1679817
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Wu Jieping Medical Foundation