Comparison of systemic inflammatory markers in total knee arthroplasty under spinal vs general anesthesia: a retrospective study
Compared to general anesthesia, spinal anesthesia was associated with a lower postoperative increase in systemic inflammatory blood markers in patients undergoing TKA. While no difference was observed in short-term clinical outcomes, these findings suggest that spinal anesthesia may offer an immunological advantage. Given the retrospective nature of the study, prospective research is warranted to determine whether these biomarker differences have meaningful clinical implications.
Authors
- Sezer Astan (ORCID: https://orcid.org/0000-0003-2435-3874)
- Serkan Karaman (ORCID: https://orcid.org/0000-0003-0534-629X)
- Vildan Kölükçü (ORCID: https://orcid.org/0000-0002-3914-3899)
- Ali Genç (ORCID: https://orcid.org/0000-0003-1392-0204)
- Hakan Tapar (ORCID: https://orcid.org/0000-0001-7625-0864)
- Ahmet Tuğrul Şahin (ORCID: https://orcid.org/0000-0002-4855-696X)
- Tuğba Karaman (ORCID: https://orcid.org/0000-0002-0724-3326)
- Mehtap Gürler Balta (ORCID: https://orcid.org/0000-0003-2360-7203)
Institutions
- Tokat Gaziosmanpaşa Üniversitesi (TR)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12871-025-03399-y
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00