Scope and Synthetic Applications of the Aryl-Alcohol Oxidase from <i>Streptomyces hiroshimensis</i> ( <i>Sh</i> AAO)
The sustainable production of carbonyl compounds is of growing interest due to their broad academic and industrial interest. Herein, we explored the aryl-alcohol oxidase from <i>Streptomyces hiroshimensis</i> (<i>Sh</i>AAO), mapping its activity across diverse alcohols, revealing a distinct profile from other natural AAOs. Integrated into tandem organocatalytic processes, <i>Sh</i>AAO enabled the synthesis of various chiral compounds, including an intermediate for paroxetine. Gram-scale reactions delivered high yields and turnover numbers exceeding 65000. Immobilization further enhanced stability, highlighting <i>Sh</i>AAO as an efficient and industrially relevant biocatalyst.
Authors
- Raquel P. Herrera (ORCID: https://orcid.org/0000-0002-5244-9569)
- Juan Mangas‐Sánchez (ORCID: https://orcid.org/0000-0002-3364-1512)
- Sebastian C. Cosgrove (ORCID: https://orcid.org/0000-0001-9541-7201)
- Christian Ascaso‐Alegre (ORCID: https://orcid.org/0000-0003-0497-8711)
- Patrícia Ferreira (ORCID: https://orcid.org/0000-0003-4076-6118)
- Paula Cinca-Fernando (ORCID: https://orcid.org/0000-0003-4929-9595)
- Tom L. Roberts
- Pablo López-Fernández
Institutions
- Universidad de Oviedo (ES)
- Universidad de Zaragoza (ES)
- Instituto de Síntesis Química y Catálisis Homogénea (ES)
- Keele University (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1021/acs.orglett.5c03814
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Keele University
- Universidad de Oviedo
- Universidad de Zaragoza
- Gobierno de Aragón
- Consejo Superior de Investigaciones Científicas
- Agencia Estatal de Investigación
- European Social Fund