Evaluating Treatment Success in CGRP Antibody Prophylaxis: A Retrospective Cohort Study Comparing Monthly Migraine Days, MIDAS Scores, and HIT-6 Scores

Outcome measures strongly influence responder classification. PROMs such as MIDAS and HIT-6 captured therapeutic benefits not reflected in MMDs reductions, especially in cases of preserved headache frequency but reduced burden. These tools may serve as valid surrogates for diary-based documentation, especially in episodic migraine. PROMs are a practical and patient-centered alternative or complement to headache diaries, particularly under routine care constraints. Regulatory frameworks and clinical guidelines should consider integrating these measures into standard practice.