Bioinformatics and experimental validation of MAPK pathway activation in diabetic kidney disease induced by glucose variability
Collectively, fluctuating hyperglycemia directly and indirectly regulates MAPK-JNK signaling via ITGB2, TYROBP, and oxidative stress, ultimately influencing the onset and progression of diabetic nephropathy.
Authors
- Sujuan Li (ORCID: https://orcid.org/0000-0002-6587-8661)
- Huijuan Wang (ORCID: https://orcid.org/0000-0003-3321-4446)
- Yuanhang Zhang (ORCID: https://orcid.org/0000-0001-9138-2347)
Institutions
- Zhejiang Chinese Medical University (CN)
- 82th Hospital of Pla (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.jgeb.2025.100598
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00