Leukoencephalopathy, a Frequent Complication After High‐Dose Methotrexate in Treatment of Osteosarcoma
MTX-associated leukoencephalopathy is frequent in osteosarcoma, even in asymptomatic patients, and often persists after treatment. Serious neurocognitive sequelae appear uncommon, but long-term cognitive monitoring is essential to detect subtle deficits.
Authors
- Laurence Brugières (ORCID: https://orcid.org/0000-0002-7798-6651)
- Anne Maraval
- Virginie Kieffer
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Pablo Berlanga (ORCID: https://orcid.org/0000-0003-1110-7789)
- Audrey Longaud
- Sandra Raimbault
- Nathalie Gaspar (ORCID: https://orcid.org/0000-0002-1827-8903)
- Lucy Métayer (ORCID: https://orcid.org/0000-0001-6682-5847)
- Blanche Bapst (ORCID: https://orcid.org/0000-0003-4958-7458)
- Jean Louis Amegnizin
Institutions
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centre Oscar Lambret (FR)
- Hôpitaux de Saint Maurice (FR)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1002/pbc.32104
- Citations
- 2
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 3.04