Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target
Our study establishes an in-depth, early-stage immune landscape of renal transplantation, revealed that the Isg15+Mac subset activates T cells via the Ccl3-Ccr5 axis and thereby serves as a critical driver of acute rejection. And indicating that Maraviroc may potentially be a therapeutic candidate for transplant rejection.
Authors
- Changhong Shi (ORCID: https://orcid.org/0000-0001-7490-3593)
- Fanchao Wei (ORCID: https://orcid.org/0009-0004-1603-2792)
- Tong Lü (ORCID: https://orcid.org/0000-0001-5691-9209)
- Ruochen Qi (ORCID: https://orcid.org/0000-0001-9073-4996)
- Zhite Zhao
- Lang Li (ORCID: https://orcid.org/0000-0001-7154-891X)
- Shuaijun Ma
- Zhaoxiang Wang (ORCID: https://orcid.org/0000-0002-7601-376X)
- Weijun Qin (ORCID: https://orcid.org/0000-0002-7509-7164)
- Lijun Yang
- Jingliang Zhang
- Zhengxuan Li (ORCID: https://orcid.org/0000-0001-9907-1543)
- Shichao Han (ORCID: https://orcid.org/0000-0001-5404-7347)
Institutions
- Air Force Engineering University (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1663251
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00