Humoral immune activation within tertiary lymphoid structures is correlated with poor outcomes in oral lichen planus and lichenoid lesions
TLS-associated B cell maturation and plasma cell infiltration define a humoral activation axis linked to unfavorable clinical outcomes in OLP/OLL. The presence of activated B cells and plasma cells correlates with erosive and recurrent disease phenotypes, highlighting their potential as prognostic biomarkers and therapeutic targets for improving disease management.
Authors
- Yufeng Wang (ORCID: https://orcid.org/0000-0003-1417-1460)
- Yirao Lai (ORCID: https://orcid.org/0009-0004-5951-5575)
- Xiaojie Yang (ORCID: https://orcid.org/0000-0001-8779-1869)
- Guoyao Tang (ORCID: https://orcid.org/0000-0003-1150-5613)
- Lei Pan (ORCID: https://orcid.org/0000-0003-3724-1783)
- Aili Dai
- Yiwen Deng (ORCID: https://orcid.org/0000-0002-6618-9155)
- Xiaozhe Han (ORCID: https://orcid.org/0000-0001-8357-1471)
- Lei Sun (ORCID: https://orcid.org/0000-0002-0101-0695)
- Xuemin Shen (ORCID: https://orcid.org/0000-0002-9646-5237)
Institutions
- Nova Southeastern University (US)
- Fudan University (CN)
- XinHua Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1667976
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00