Exposome, oxidative stress and inflammation in persons with multiple sclerosis: the EXPOSITION study protocol
The exposome represents the totality of external and internal exposures an individual encounters throughout life and plays a critical role in developing many chronic diseases, including multiple sclerosis (MS). MS is a multifactorial disease influenced by both genetic and environmental factors. The EXPOSITION study (registered on www.clinicaltrials.gov, NCT06325358) aims to investigate the association between environmental exposures (external exposome) and biological markers of oxidative stress and inflammation (internal exposome) in people with MS. This cross-sectional study will involve 200 individuals with MS, assessed for lifestyle and occupational variables and biological markers, including circulating microRNAs, neurofilament light chains, pro- and anti-inflammatory cytokines, and gut/nasal microbiota composition. The study will use advanced statistical models, such as generalised linear models and multivariate analyses, to assess associations between external exposures and biological outcomes. By integrating both environmental and biological factors, this research aims to deepen our understanding of MS mechanisms, providing insights that could lead to targeted interventions, personalised therapies, and public health strategies to mitigate MS progression.
Authors
- Clarissa Consolandi (ORCID: https://orcid.org/0000-0002-9328-9557)
- Stefano Decesari (ORCID: https://orcid.org/0000-0001-6486-3786)
- Matteo Gastaldi (ORCID: https://orcid.org/0000-0003-2288-2000)
- Alessia Lo Dico (ORCID: https://orcid.org/0000-0002-8627-5050)
- Roberto Bergamaschi (ORCID: https://orcid.org/0000-0002-1397-511X)
- Francesca Gallivanone (ORCID: https://orcid.org/0000-0001-6559-6157)
- Roberta Pernetti (ORCID: https://orcid.org/0000-0002-5925-1352)
- Eleonora Tavazzi (ORCID: https://orcid.org/0000-0003-2580-3646)
- Rachele De Giuseppe (ORCID: https://orcid.org/0000-0002-5583-7735)
- Elena Ballante (ORCID: https://orcid.org/0000-0003-3217-8930)
- Bruno G. Galuzzi (ORCID: https://orcid.org/0000-0002-8518-5352)
- Francesca Costabile (ORCID: https://orcid.org/0000-0002-9590-3776)
- Enrico Oddone (ORCID: https://orcid.org/0000-0001-8503-6560)
- Clarissa Gervasoni (ORCID: https://orcid.org/0000-0003-0740-502X)
- Federica Loperfido (ORCID: https://orcid.org/0000-0003-4138-7793)
- Maria Cristina Monti (ORCID: https://orcid.org/0000-0003-1586-527X)
- Cristina Ceriani (ORCID: https://orcid.org/0000-0002-9442-6250)
- Αliki Kalmpourtzidou (ORCID: https://orcid.org/0000-0001-7737-4367)
- Mulubirhan Assefa Alemayohu (ORCID: https://orcid.org/0000-0001-8370-019X)
- Gemine Vivone (ORCID: https://orcid.org/0000-0001-9542-0638)
- Camilla Ceccarani (ORCID: https://orcid.org/0000-0003-3824-7239)
- A. Scarabotto (ORCID: https://orcid.org/0000-0003-2290-9672)
- Beatrice Maccarini
- Hellas Cena (ORCID: https://orcid.org/0000-0002-5752-6199)
- Cristina Montomoli (ORCID: https://orcid.org/0000-0002-8526-5846)
- Antonio Mazza (ORCID: https://orcid.org/0000-0002-7961-1669)
- Gloria Bertoli (ORCID: https://orcid.org/0000-0002-5901-4269)
- Ghanya Al‐Naqeb (ORCID: https://orcid.org/0000-0002-7734-1706)
- Tania Camboni
- Donato Summa (ORCID: https://orcid.org/0000-0002-0867-4144)
- Tony Christian Landi (ORCID: https://orcid.org/0000-0002-5969-6677)
- Danilo Porro (ORCID: https://orcid.org/0000-0001-5723-3700)
- Marco Severgnini (ORCID: https://orcid.org/0000-0001-8655-1206)
- Elena Colombo (ORCID: https://orcid.org/0000-0002-5265-5055)
- Francesca Sellaro
- Noemi Paulin
- Chiara Pellizzer
- Simona Gugiatti
- Teresa Itri
- Aurora Lanzotti
Institutions
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Institute of Molecular Bioimaging and Physiology (IT)
- Institute of Atmospheric Sciences and Climate (IT)
- CNR-IMIOT – Consiglio Nazionale delle Ricerche - Istituto di Metodologie Integrate per l’Osservazione della Terra (IT)
- Institute of Biostructure and Bioimaging (IT)
- Institute for Complex Systems (IT)
- Institute of Biomedical Technologies (IT)
- National Research Council (IT)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fpubh.2025.1688158
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission