Exploring ceRNA mechanisms in COVID-19 mRNA vaccine-induced myocarditis: implications for future vaccine design
This study elucidated a molecular mechanism linking COVID-19 mRNA vaccines to myocarditis and highlighted the ceRNA-mediated crosstalk between IVT mRNA and IL-6. These findings underscore the importance of avoiding critical microRNA binding sites in the design of next-generation mRNA vaccine sequences to improve safety.
Authors
- Ning Du (ORCID: https://orcid.org/0000-0001-5394-8776)
- Xi‐Yuan Ge (ORCID: https://orcid.org/0000-0002-6012-2398)
- Xin-Yi Sun (ORCID: https://orcid.org/0009-0001-2299-4726)
- Jing Wang (ORCID: https://orcid.org/0000-0003-3185-1724)
- Minfeng Xiao (ORCID: https://orcid.org/0000-0002-0507-7352)
- Min Fu (ORCID: https://orcid.org/0000-0002-2038-9039)
- Qian Gao (ORCID: https://orcid.org/0000-0002-0485-1596)
Institutions
- King University (US)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Digital China Health (China) (CN)
- Peking University School and Hospital of Stomatology (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1674049
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China