Metabolomics reveals the mechanisms of action of fosfomycin and azithromycin combination in the treatment of Pseudomonas aeruginosa
Fosfomycin-azithromycin combination therapy exerted stronger interference on the metabolic pathways of <i>P. aeruginosa</i> than either drug alone, indicating more substantial metabolic alterations at the cellular level. These findings provide mechanistic insights that may help inform the potential application of combination regimens against multidrug-resistant <i>P. aeruginosa</i> in the clinic.
Authors
- Mingming Yu (ORCID: https://orcid.org/0000-0001-9504-891X)
- Sherwin K. B. Sy (ORCID: https://orcid.org/0000-0001-6405-9130)
- Yiran Zhao (ORCID: https://orcid.org/0000-0002-0841-967X)
- Hai Yang (ORCID: https://orcid.org/0000-0001-5210-8468)
- Meng Song (ORCID: https://orcid.org/0000-0003-3084-993X)
- Xiaoli Cao (ORCID: https://orcid.org/0000-0001-5928-6304)
- Shuo Diao
- Ziyun Zhao
- Zhihua Lv (ORCID: https://orcid.org/0000-0002-5505-9902)
Institutions
- Qingdao University (CN)
- Universidade Estadual de Maringá (BR)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fcimb.2025.1663542
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00