DOCK3 orchestrates metastasis and immune microenvironment in prostate cancer
DOCK3 drives PCa metastasis through cytoskeletal dynamics while paradoxically promoting an immunologically active microenvironment. Its tumor-specific expression and association with aggressive clinical features nominate DOCK3 as a novel biomarker for risk stratification and a promising therapeutic target for combinatorial immunotherapy in immunologically "cold" PCa.
Authors
- Qiao Xiong (ORCID: https://orcid.org/0000-0003-2259-9096)
- Ping Tan (ORCID: https://orcid.org/0000-0002-7445-3577)
- Haipeng Zhou (ORCID: https://orcid.org/0000-0002-2240-5362)
- Ming Zhang (ORCID: https://orcid.org/0000-0001-6574-3006)
- Junsong Han (ORCID: https://orcid.org/0000-0002-9405-9382)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Urology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fruro.2025.1662692
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00