Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040
Although the global MS burden among adolescents and young adults (AYAs) decreased, the substantial and rising prevalence demands attention. The burden from premature mortality and stark geographic variations in prevalence and DALYs indicate inadequate disease management, underscoring the need for enhanced awareness and effective interventions. Urgent, targeted healthcare policies are required to address geographical inequities, sex-specific pathophysiology, and modifiable risk factors such as smoking.
Authors
- B. Wang
- Peng Xu (ORCID: https://orcid.org/0009-0006-0222-3234)
- Hongmei Nan (ORCID: https://orcid.org/0000-0002-9957-616X)
- Lin Huang (ORCID: https://orcid.org/0000-0001-8254-7664)
- Chang Guan
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5477-8297)
- Ding Ye (ORCID: https://orcid.org/0000-0001-6654-7832)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9386-7986)
- Peixi Zhao
- Jing Lu (ORCID: https://orcid.org/0000-0002-7559-6123)
Institutions
- Zhejiang Chinese Medical University (CN)
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1685316
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Multiple Sclerosis International Federation