Top motor and non-motor complaints in patients with Parkinson's disease

Overall, tremor was the most troublesome symptom in patients with PD, though high variability was observed. Approximately 69% of patients had at least one non-motor symptom among their top-3 complaints, which was associated with abnormal cognitive status. Speech difficulties, dyskinesia, and insomnia became more prominent with disease progression. Among patients with non-motor symptoms in the top three tiers, those with a PIGD phenotype or prominent dyskinesia exhibited a higher frequency of fatigue, insomnia, pain, and anxiety, suggesting a clustering effect of non-motor symptoms with these motor presentations.