Development of a ferroptosis-related signature and identification of NOTCH2 as a novel prognostic biomarker in pancreatic cancer
Our study establishes a ferroptosis-related signature for prognostic prediction in pancreatic cancer and identifies NOTCH2 as a critical prognostic biomarker. NOTCH2 may promote pancreatic cancer progression by suppressing ferroptosis, highlighting it as a potential therapeutic target.
Authors
- Jing Guo (ORCID: https://orcid.org/0000-0002-2595-7314)
- Xiangxue Li (ORCID: https://orcid.org/0000-0002-1779-6178)
- Siyi Zhang (ORCID: https://orcid.org/0000-0003-2096-087X)
- Kaihui Zhu
- Ziheng Zhang (ORCID: https://orcid.org/0000-0002-5938-4729)
- Xiaoxuan Li (ORCID: https://orcid.org/0009-0008-1097-7727)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Jimo District Qingdao Hospital of Traditional Chinese Medicine (CN)
- Qingdao Eighth People's Hospital (CN)
- Shanghai Huangpu District Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1659652
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00