Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and <scp>HCC</scp> Surveillance in Non‐Cirrhotic Patients
East Asia Pacific (EAP) faces a high burden of chronic liver disease (CLD), with metabolic dysfunction-associated steatotic liver disease (MASLD) projected to account for about 80% of CLD prevalence by 2040. Using Global Burden of Disease 2021 data, we assessed CLD trends, transitions to hepatocellular carcinoma (HCC), and the cost-effectiveness of non-cirrhotic HCC surveillance. Despite declining viral hepatitis burden, MASLD and alcohol-related CLD have risen. HCC surveillance in non-cirrhotic patients was cost-effective only for chronic hepatitis B in selected older age groups, with substantial variability across countries. These findings support refining surveillance guidelines and adaptation of risk stratification tools.
Authors
- Xiaolong Qi (ORCID: https://orcid.org/0000-0002-3559-5855)
- Tsz Ngai Mok (ORCID: https://orcid.org/0000-0002-4256-3333)
- Wai‐Kit Ming (ORCID: https://orcid.org/0000-0002-8846-7515)
- Chuan Liu (ORCID: https://orcid.org/0000-0003-0642-3154)
- Ming Liu (ORCID: https://orcid.org/0000-0002-6531-2879)
Institutions
- City University of Hong Kong (HK)
- Hong Kong Jockey Club (HK)
- Zhongda Hospital Southeast University (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Southeast University (CN)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1111/apt.70428
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- City University of Hong Kong