Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and <scp>HCC</scp> Surveillance in Non‐Cirrhotic Patients

East Asia Pacific (EAP) faces a high burden of chronic liver disease (CLD), with metabolic dysfunction-associated steatotic liver disease (MASLD) projected to account for about 80% of CLD prevalence by 2040. Using Global Burden of Disease 2021 data, we assessed CLD trends, transitions to hepatocellular carcinoma (HCC), and the cost-effectiveness of non-cirrhotic HCC surveillance. Despite declining viral hepatitis burden, MASLD and alcohol-related CLD have risen. HCC surveillance in non-cirrhotic patients was cost-effective only for chronic hepatitis B in selected older age groups, with substantial variability across countries. These findings support refining surveillance guidelines and adaptation of risk stratification tools.

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Publication Details

Journal
Alimentary Pharmacology & Therapeutics
Published
2025-10-21
DOI
https://doi.org/10.1111/apt.70428
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and HCC Surveillance in Non‐Cirrhotic Patients

Xiaolong Qi, Tsz Ngai Mok, Wai‐Kit Ming, Chuan Liu et al.
Alimentary Pharmacology & Therapeutics
Liver Disease Diagnosis and Treatment
article

Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and HCC Surveillance in Non‐Cirrhotic Patients

Xiaolong Qi, Tsz Ngai Mok, Wai‐Kit Ming, Chuan Liu, Ming Liu
article en

Abstract

East Asia Pacific (EAP) faces a high burden of chronic liver disease (CLD), with metabolic dysfunction-associated steatotic liver disease (MASLD) projected to account for about 80% of CLD prevalence by 2040. Using Global Burden of Disease 2021 data, we assessed CLD trends, transitions to hepatocellular carcinoma (HCC), and the cost-effectiveness of non-cirrhotic HCC surveillance. Despite declining viral hepatitis burden, MASLD and alcohol-related CLD have risen. HCC surveillance in non-cirrhotic patients was cost-effective only for chronic hepatitis B in selected older age groups, with substantial variability across countries. These findings support refining surveillance guidelines and adaptation of risk stratification tools.

Alimentary Pharmacology & TherapeuticsVol. 63(4)
City University of Hong Kong (HK), Hong Kong Jockey Club (HK), Zhongda Hospital Southeast University (CN), State Key Laboratory of Digital Medical Engineering (CN), Southeast University (CN)
City University of Hong Kong
Openalex Percentile: Top 60%
Liver Disease Diagnosis and Treatment
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Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and <scp>HCC</scp> Surveillance in Non‐Cirrhotic Patients — Xiaolong Qi, Tsz Ngai Mok, et al. · Alimentary Pharmacology & Therapeutics (2025) | TGRS Research Map | TGRS