Significant matrix effect in fludarabine quantification in plasma: implications for CAR-T cell therapy monitoring
This experience highlights the importance of complementing standard validation tests with analyses in each patient's plasma, collected immediately before FLU infusion, to ensure reliable TDM to support CAR T-cell therapy.
Authors
- Marco Zecca (ORCID: https://orcid.org/0000-0002-8818-1744)
- Simona De Gregori (ORCID: https://orcid.org/0000-0002-9627-8730)
- Riccardo Albertini (ORCID: https://orcid.org/0000-0003-0462-0867)
- Mara Capone (ORCID: https://orcid.org/0009-0006-9934-076X)
Institutions
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Bioanalysis
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1080/17576180.2025.2577085
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00