MODY PDX1P33T: a mouse model reveals phenotypic divergence from human disease
Our work indicates substantial differences between mouse and human PDX1 function in the pancreas. Further refinement of animal models is necessary to better elucidate the pathophysiology of PDX1-MODY.
Authors
- Martin Hrabě de Angelis (ORCID: https://orcid.org/0000-0002-7898-2353)
- Raffaele Teperino (ORCID: https://orcid.org/0000-0001-8815-1409)
- Florian Giesert (ORCID: https://orcid.org/0000-0001-6825-8858)
- Gerhard K. H. Przemeck (ORCID: https://orcid.org/0000-0003-3730-3454)
- Michaela Schmidtke (ORCID: https://orcid.org/0000-0001-9163-5682)
- David A. Skerrett‐Byrne (ORCID: https://orcid.org/0000-0002-1804-1826)
- Ami Harten
Institutions
- Helmholtz Zentrum München (DE)
- Hunter Medical Research Institute (AU)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fendo.2025.1680893
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- National Health and Medical Research Council
- Helmholtz Zentrum München