Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID

This study maps the immune landscape of COVID-19 and Long COVID at single-cell resolution, revealing that persistent immune cell communication, particularly involving memory CD8<sup>+</sup> T cells, may sustain chronic inflammation beyond the acute phase. The identified molecular signatures offer potential biomarkers and therapeutic targets for mitigating post-viral inflammatory syndromes.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-10-22
DOI
https://doi.org/10.3389/fimmu.2025.1689507
Primary Topic
COVID-19 Clinical Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID

Hengrui Liu, Jieling Weng, Panpan Wang, Zewen Xu et al.
Frontiers in Immunology
COVID-19 Clinical Research Studies
article

Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID

Hengrui Liu, Jieling Weng, Panpan Wang, Zewen Xu, Ilayda Karsidag
article en

Abstract

This study maps the immune landscape of COVID-19 and Long COVID at single-cell resolution, revealing that persistent immune cell communication, particularly involving memory CD8<sup>+</sup> T cells, may sustain chronic inflammation beyond the acute phase. The identified molecular signatures offer potential biomarkers and therapeutic targets for mitigating post-viral inflammatory syndromes.

Frontiers in ImmunologyVol. 16
University of San Diego (US), University of California San Diego (US), Second Affiliated Hospital of Guangzhou Medical University (CN), First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN), Guangdong Provincial Hospital of Traditional Chinese Medicine (CN), First Affiliated Hospital of Jinan University (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 64%
COVID-19 Clinical Research Studies
DOIOpen Access PDFOpenAlex
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Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID — Hengrui Liu, Jieling Weng, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS