Mechanism of Herbal Pairs Modulating Endogenous Melatonin to Ameliorate Sleep Disorders: Data Mining, Network Pharmacology andMeta-Analysis
Meta-analysis and network pharmacology suggest that the PA-BR pair might offer superior efficacy by modulating membrane potential and nicotine addiction pathways, targeting GRIN2A, GRIN1, GRIN3A, and GRIN2B to regulate melatonin levels.
Authors
- Tao Sun
- Danni Xie
- Jiyan Dai (ORCID: https://orcid.org/0000-0002-7720-8032)
- Zhenwei Zhai
- Jie Cai (ORCID: https://orcid.org/0000-0002-6561-5626)
- Sha Huang (ORCID: https://orcid.org/0000-0001-8419-0320)
- Tao Jiang (ORCID: https://orcid.org/0000-0001-8296-3027)
- Zhishan Zhu
- Ying Xu (ORCID: https://orcid.org/0000-0002-7504-7896)
- Fanjing Kong (ORCID: https://orcid.org/0009-0004-1453-8562)
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-10-20
- DOI
- https://doi.org/10.2174/0113862073393993250930120235
- Primary Topic
- Ziziphus Jujuba Studies and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00