The CILLO-E Hypothesis: Erythrocyte-Driven Acidosis and Early Eryptosis as Drivers of Cancer-Associated Anemia
The CILLO-E hypothesis reframes erythrocytes as active metabolic targets in the TME rather than passive oxygen carriers. By linking lactate-driven metabolic stress to erythrocyte dysfunction, anemia, and systemic hypoxia, it suggests a feedback loop that promotes tumor progression and highlights opportunities for erythrocyte-based biomarkers and therapeutic strategies.
Authors
- Hüseyin Aydın (ORCID: https://orcid.org/0000-0002-3194-830X)
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fonc.2025.1697588
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00