TyG × waist circumference composite indicator and cardiovascular disease risk in older adults across multiple regions: a cross-sectional study

The TyG×WC composite indicator is an independent predictor of CVD risk, with more pronounced effects observed in women and the general population. The association between TyG×WC and CVD risk demonstrates a stable and progressive trend across quartiles and is consistent across different populations. The inclusion of TyG×WC enhances predictive accuracy (AUC, NRI, IDI) and clinical utility (DCA), suggesting strong generalizability and practical application. This indicator may serve as a valuable tool for screening high-risk individuals and guiding CVD prevention strategies.