Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with severe ischemia-reperfusion injury and delayed graft function
Together, our study characterizes the transcriptional signature of severe IRI during NMP, suggesting the role of pro-inflammatory innate/pro-fibrotic cells in this process. We describe a transcriptomic signature that may support future prospective therapeutic trials as a potential efficacy endpoint, and highlight potential cellular targets for therapeutic intervention during NMP in an era of precision medicine.
Authors
- Anna Paterson (ORCID: https://orcid.org/0000-0002-1494-0875)
- Michael L. Nicholson (ORCID: https://orcid.org/0000-0001-7620-0664)
- Vasilis Kosmoliaptsis (ORCID: https://orcid.org/0000-0001-7298-1387)
- Serena MacMillan (ORCID: https://orcid.org/0000-0002-8742-5452)
- Harry Spiers (ORCID: https://orcid.org/0000-0001-7308-2711)
- Ying Zhai (ORCID: https://orcid.org/0000-0002-2674-4353)
- Irina Mohorianu (ORCID: https://orcid.org/0000-0003-4863-761X)
- L. J. Stadler
- Sarah A. Hosgood (ORCID: https://orcid.org/0000-0002-8039-143X)
- Miguel Larraz
- Haeun Moon
Institutions
- NHS Blood and Transplant (GB)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Bridge University (SS)
- Addenbrooke's Hospital (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1679251
- Citations
- 1
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.01