Computational Analysis and in vitro Verification Insights into Quercetin’s Suppression of Neuroinflammation in BV-2 Microglia through NF-κB Pathway Inhibition
Quercetin effectively suppressed neuroinflammation in microglial cells through inhibition of the NF-κB signaling pathway, reducing levels of critical pro-inflammatory mediators. The outcomes have highlighted the potential of quercetin as a preventive nutraceutical for neurodegenerative diseases, necessitating future in vivo investigations to confirm its therapeutic efficacy.
Authors
- Lemmuel L. Tayo (ORCID: https://orcid.org/0000-0002-0869-2131)
- Marineil C. Gomez (ORCID: https://orcid.org/0000-0001-6238-5709)
- Cheng‐Hung Chuang (ORCID: https://orcid.org/0000-0003-1963-1825)
- Po‐Wei Tsai (ORCID: https://orcid.org/0000-0002-1981-5360)
- Shu‐Ming Huang
- Cheng Yang Hsieh
Institutions
- Ministry of Health and Welfare (KR)
- Mapúa University (PH)
- National Taiwan Ocean University (TW)
- National Ilan University (TW)
- Hungkuang University (TW)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-10-17
- DOI
- https://doi.org/10.2174/0109298673395813250901012530
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00