Successful Treatment of Paediatric Necrobiosis Lipoidica With Baricitinib

ABSTRACT Necrobiosis lipoidica (NL) is a rare, chronic granulomatous condition that typically presents as sharply demarcated plaques with telangiectasia and atrophic centres. Paediatric cases are uncommon, and treatment options often fail to address refractory cases. We report a 13‐year‐old girl with progressive NL lesions that responded successfully to oral baricitinib, a Janus kinase inhibitor. Initial management with topical and systemic corticosteroids failed, but baricitinib led to significant lesion improvement within 6 months. This case highlights the potential of baricitinib in refractory paediatric NL and underscores the need for further research on its long‐term efficacy and safety.

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Publication Details

Journal
JEADV Clinical Practice
Published
2025-10-21
DOI
https://doi.org/10.1002/jvc2.70194
Primary Topic
Skin Diseases and Diabetes
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article
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article

Successful Treatment of Paediatric Necrobiosis Lipoidica With Baricitinib

Maria João Paiva Lopes, Pedro Simões Farinha
JEADV Clinical Practice
Skin Diseases and Diabetes
article

Successful Treatment of Paediatric Necrobiosis Lipoidica With Baricitinib

Maria João Paiva Lopes, Pedro Simões Farinha
article en

Abstract

ABSTRACT Necrobiosis lipoidica (NL) is a rare, chronic granulomatous condition that typically presents as sharply demarcated plaques with telangiectasia and atrophic centres. Paediatric cases are uncommon, and treatment options often fail to address refractory cases. We report a 13‐year‐old girl with progressive NL lesions that responded successfully to oral baricitinib, a Janus kinase inhibitor. Initial management with topical and systemic corticosteroids failed, but baricitinib led to significant lesion improvement within 6 months. This case highlights the potential of baricitinib in refractory paediatric NL and underscores the need for further research on its long‐term efficacy and safety.

JEADV Clinical PracticeVol. 5(1)
Unidade Local de Saúde de São José (PT), Hospital de São José (PT), Centro Hospitalar Lisboa Norte (PT), Universidade Nova de Lisboa (PT)
Openalex Percentile: Top 49%
Skin Diseases and Diabetes
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Successful Treatment of Paediatric Necrobiosis Lipoidica With Baricitinib — Maria João Paiva Lopes, Pedro Simões Farinha · JEADV Clinical Practice (2025) | TGRS Research Map | TGRS