<scp> <i>Euphorbia pekinensis</i> </scp> glycosphingolipids disrupt gut motility and fluid balance via TRPA1 activation in enterochromaffin cells
This research reveals that the gut toxicity of EP is driven by a previously unrecognized GSL-TRPA1-5-HT signalling pathway in the intestinal epithelium. These findings provide a clear mechanistic basis for EP-induced diarrhoea and highlight a potential new target for managing gut toxicity.
Authors
- Huimin Bian
- Hao Wu (ORCID: https://orcid.org/0000-0002-7281-8579)
- Xiaobin Cui
- Xingde Zhang (ORCID: https://orcid.org/0009-0007-1074-968X)
- Yu‐Xin Gu
- Kejin Zhang (ORCID: https://orcid.org/0000-0002-4980-1736)
- Changli Shen
- Xin Li (ORCID: https://orcid.org/0000-0003-2999-9818)
- Sheng Li (ORCID: https://orcid.org/0000-0003-1205-8632)
- Zeneng Cheng (ORCID: https://orcid.org/0000-0001-9352-9744)
- Ming Zeng (ORCID: https://orcid.org/0000-0001-9717-1751)
- Hongli Yu (ORCID: https://orcid.org/0000-0003-4375-0496)
- Xinzhi Wang (ORCID: https://orcid.org/0000-0001-8382-7203)
- Renbo Yu (ORCID: https://orcid.org/0000-0003-4767-4240)
- Yiqing Xu
- Bingbing Liu (ORCID: https://orcid.org/0000-0002-8091-8908)
- Jie Cao
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1111/bph.70219
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00