Integrase Strand Transfer Inhibitors for Treatment-experienced Young Adults With Perinatal HIV in the US: Immunologic, Virologic, and Anthropometric Outcomes
Individual INSTI-based regimens among treatment-experienced AYAPHIV had moderate effectiveness with respect to viral suppression. Continued average weight gain across INSTIs raises concerns about long-term cardiometabolic sequalae.
Authors
- Everlyne Akoth Odero (ORCID: https://orcid.org/0000-0001-6633-7421)
- Shelley Buschur
- George R. Seage (ORCID: https://orcid.org/0000-0001-5657-2970)
- Juan Caffroni
- Sonia Hernández–Dı́az (ORCID: https://orcid.org/0000-0003-1458-7642)
- Ellen G. Chadwick
- Juliette Johnson
- Elizabeth J. McFarland (ORCID: https://orcid.org/0000-0003-0653-8955)
- Anai Cuadra
- Russell Van Dyke
- Stephen A. Spector (ORCID: https://orcid.org/0000-0002-1882-4855)
- Alma Villegas
- Ray Shaw
- Nicolas Rosario
- Veronica Figueroa
- Karen Surowiec
- Marlene Burey
- Paige L. Williams (ORCID: https://orcid.org/0000-0002-7160-574X)
- Jennifer Jao
- Patricia A. Sirois (ORCID: https://orcid.org/0000-0001-6790-6681)
- Chivon McMullen-Jackson
- Janet S. Chen
- Katherine M. Knapp (ORCID: https://orcid.org/0000-0002-8474-3359)
- Sandra K. Burchett (ORCID: https://orcid.org/0000-0002-7106-9262)
- T.C. White
- Ayesha Mirza (ORCID: https://orcid.org/0000-0002-2671-0903)
- Vivian Olivera
- Murli Purswani (ORCID: https://orcid.org/0000-0001-6902-7779)
- Carrie Chambers
- Allison L. Agwu (ORCID: https://orcid.org/0000-0002-8449-222X)
- Kunjal Patel (ORCID: https://orcid.org/0000-0003-0002-681X)
- Brad Karalius
- Rohit Kalra
- Medea Gabriel
- Kathleen Malee (ORCID: https://orcid.org/0000-0002-6384-1283)
- Tracy Wolbach
- Chul‐Hoon Kwon (ORCID: https://orcid.org/0000-0001-9630-1550)
- Mitzie Grant (ORCID: https://orcid.org/0000-0001-8691-4978)
- Tzy‐Jyun Yao (ORCID: https://orcid.org/0000-0001-7744-5057)
- Megan Loughran
- Sharon L. Nichols (ORCID: https://orcid.org/0000-0003-2778-811X)
- Patricia A. Garvie (ORCID: https://orcid.org/0000-0003-4703-0808)
- Michelle E. Anderson (ORCID: https://orcid.org/0000-0003-3230-4677)
- Suzanne Siminski (ORCID: https://orcid.org/0000-0003-4686-2258)
- Heida Rios
- Martha Cavallo
- Megan Wilkins (ORCID: https://orcid.org/0009-0007-8520-6292)
- Emanuela Lartey
- Gwendolyn Scott
- Lynnette Harris (ORCID: https://orcid.org/0009-0001-1611-6118)
- Mary Paul
- Mahboobullah Mirza Baig
- Russell B. Van Dyke
- Patrick J. Davis
- Margarita Silió
- Grace Alvarez
- Andrew Wiznia (ORCID: https://orcid.org/0000-0001-7487-1894)
- Arry Dieudonne
- Lisa-Gaye Robinson
- Alan Bernegger
- Christine M Salois
- Robin McEnvoy
- Alicia Jaramillo-Underwood
Institutions
- Northwestern University (US)
- Tulane University (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Florida (US)
- Cancer Research And Biostatistics (US)
- Florida College (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1093/cid/ciaf538
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- University of Miami
- Tulane University
- Harvard T.H. Chan School of Public Health
- National Institutes of Health
- University of California, San Diego
- University of Colorado Denver
- National Institute on Alcohol Abuse and Alcoholism
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Cancer Institute
- National Institute on Deafness and Other Communication Disorders
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke
- National Institute of Dental and Craniofacial Research