Varespladib Alleviates Colonic Inflammation Induced by High‐Fat Diet via Downregulating the TGF‐β/Smad Pathway and AA Pathway by Inhibiting sPLA <sub>2</sub>
Short-term HFD induced intestinal inflammation. These disorders are mainly triggered by sPLA<sub>2</sub> upregulation, resulting in activation of the arachidonic acid and TGF-β/smad pathways. Varespladib has significant therapeutic potential for alleviating HFD-induced colonic inflammation in mice.
Authors
- Ying Xiong (ORCID: https://orcid.org/0000-0003-0586-0109)
- Linfeng Wang
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-3332-8128)
- Chunhong Huang (ORCID: https://orcid.org/0000-0002-1042-4355)
- Jiahao Liu (ORCID: https://orcid.org/0000-0002-1843-0610)
- Meng Shirui
- Zhou Daixuan
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1111/jgh.70130
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00