Physical Compatibility of Ertapenem and Meropenem in 0.45% Normal Saline and Plasma-Lyte A.

Our results are the first that have demonstrated physical compatibility for ertapenem 10 mg/mL and 20 mg/mL in 0.45% sodium chloride and Plasma-Lyte A. The findings of this meropenem analysis confirm a previous report that evaluated simulated Y-site samples at 1 hour but expanded upon those findings to show physical compatibility at 8 hours and 5 hours for the 10 mg/mL in both fluids and 20 mg/mL in 0.45% sodium chloride concentrations, respectively. Previously published reports of the stability of meropenem indicating a concentration and temperature-dependent are confirmed by this analysis. Chemical stability studies should be undertaken to support these results.