The interplay of tumor suppressor p53 and oxidative stress in pancreatic β-cell apoptosis and insulin resistance in newly diagnosed type 2 diabetes mellitus

The results highlight the interplay of apoptosis and oxidative stress in inducing β-cell dysfunction and insulin resistance in newly diagnosed T2DM. Oxidative stress contributes to β-cell dysfunction, while p53 contributes to the development of insulin resistance, possibly by inducing oxidative stress.