IGF1R deficiency mitigates acute lung injury by promoting anti-inflammatory transcriptional profiles
IGF1R is a key modulator of the inflammatory and molecular response to ALI pathogenesis. IGF1R deficiency dampens the "cytokine storm", modifies transcriptional and epigenetic profiles and promotes protective cellular responses. These findings highlight IGF1R signaling as a potential therapeutic target in ARDS and related lung injuries.
Authors
- José G. Pichel (ORCID: https://orcid.org/0000-0001-8580-0952)
- Elvira Alfaro‐Arnedo (ORCID: https://orcid.org/0000-0002-5954-8201)
- Icíar P. López (ORCID: https://orcid.org/0000-0002-5905-2978)
- María de Toro (ORCID: https://orcid.org/0000-0003-3329-0203)
- Alfredo Urtubia
- Marta Canalejo
- Sergio Piñeiro‐Hermida (ORCID: https://orcid.org/0000-0002-8915-5687)
- Judith Beni-Ledesma
Institutions
- Spanish Clinical Research Network (ES)
- Center for Biomedical Research of La Rioja (ES)
- Medical Research Network (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1186/s12931-025-03339-x
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56