Vit D mitigates metabolic syndrome-induced hepatic damage via antioxidant, anti-inflammatory, and AMPK/PI3K signaling pathways in rats
MetS increased oxidative stress, TNF-α, liver enzymes, HOMA-IR, and ABP while reducing adiponectin and AMPK/PI3K. Vit D reversed these effects, suppressing GFAP/MMP9 and restoring metabolic balance. <b>Conclusion:</b> Vit D mitigates MetS-induced liver damage via AMPK/PI3K activation, exerting antioxidant and anti-inflammatory effects.
Authors
- Eman Sweed (ORCID: https://orcid.org/0000-0003-3689-2648)
- Marwa Mohammed Ibrahim Mohammed Khalil
- Marwa M. Adel
- Nader G. Zaki
- Suzan A Khodir (ORCID: https://orcid.org/0000-0002-2535-9445)
- Nahla Badr (ORCID: https://orcid.org/0000-0003-1408-0227)
Institutions
- Egypt-Japan University of Science and Technology (EG)
- University of Al-Qadisiyah (IQ)
- Universitas 17 Agustus 1945 Semarang (ID)
- Menoufia University (EG)
- Delta University for Science and Technology (EG)
Publication Details
- Journal
- Archives of Physiology and Biochemistry
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1080/13813455.2025.2573343
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00