T1rho imaging of head and neck cancer: its association with pathological and immunohistochemical biomarkers in nasopharyngeal carcinoma
Our results showed the possible underlying biological mechanisms of T1rho imaging in head and neck cancer. T1rho imaging negatively correlated with the ratio of collagenous to lymphoid stroma, and positively correlated with tumour cell proliferation, which are both known to be predictors of outcome, suggesting that T1rho imaging may have a valuable role in head and neck cancer imaging. As this is a preliminary study with small sample size, further studies are encouraged to validate our findings.
Authors
- Lun M. Wong (ORCID: https://orcid.org/0000-0002-6047-4609)
- Qi Yong H. Ai (ORCID: https://orcid.org/0000-0002-1155-4389)
- Frankie Mo (ORCID: https://orcid.org/0000-0002-0566-3212)
- Angela Zaneta Chan
- Weitian Chen (ORCID: https://orcid.org/0000-0001-7242-9285)
- Ann D. King (ORCID: https://orcid.org/0000-0002-5280-8349)
- Zhifeng Yu (ORCID: https://orcid.org/0000-0002-2224-8344)
- Ho Sang Leung (ORCID: https://orcid.org/0000-0003-0503-8510)
- Amy BW Chan
- Joyce Kwok Wing Lam
Institutions
- Hospital Authority (HK)
- Department of Health (CN)
- Chinese University of Hong Kong (HK)
- Tuen Mun Hospital (CN)
- Hong Kong Jockey Club (HK)
- Prince of Wales Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cancer Imaging
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s40644-025-00940-7
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese University of Hong Kong