BMSC-derived exosomal lncRNA-ZFAS1 regulates the proliferation and differentiation of osteoblasts via the miR-9/IGF-1 signaling axis
We have shown that ZFAS1 from BMSC-derived EXOs enhances the proliferation and differentiation of osteoblasts by regulating the miR-9/IGF-1 signaling axis. This discovery provides novel insights into mechanisms of osteoblast proliferation and differentiation, and identifies potential therapeutic targets for treating associated diseases.
Authors
- Zhiqiang Ma (ORCID: https://orcid.org/0000-0002-5555-2764)
- Xinlian Li (ORCID: https://orcid.org/0000-0002-1666-6953)
- Haoran Wang (ORCID: https://orcid.org/0000-0003-2292-9227)
- Gang Lv (ORCID: https://orcid.org/0000-0001-9888-7516)
- Yibin Liu (ORCID: https://orcid.org/0009-0003-7775-0221)
- Fang Xu (ORCID: https://orcid.org/0000-0003-0767-1272)
- Hui Sun (ORCID: https://orcid.org/0000-0002-2998-7772)
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Xinjiang Uygur Autonomous Region Uygur Medicine Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s13018-025-06310-0
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00