Efficacy and safety of intravenous tenecteplase thrombolysis in diffusion-weighted imaging-negative posterior circulation ischemic stroke
In patients with DWI-negative PCIS, TNK increased the proportion of patients achieving a mRS score of 0-1, reduced the incidence of END, improved long-term prognosis, and demonstrated a favorable safety profile; in contrast, the control group exhibited a higher incidence of END and poorer overall prognosis. Notably, this study has limitations, including its single-center retrospective design and small sample size after PSM, which may restrict the generalizability of the present findings.
Authors
- Shengjie Hu (ORCID: https://orcid.org/0000-0002-9374-3131)
- Shengqi Fu (ORCID: https://orcid.org/0000-0003-3335-6102)
- Baoyang Shi
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5166-534X)
- Liang Song (ORCID: https://orcid.org/0000-0001-5264-4578)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Dongdong Yang (ORCID: https://orcid.org/0000-0002-7173-5149)
- Jiarong Li (ORCID: https://orcid.org/0009-0000-8717-4342)
Institutions
- Henan University (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3389/fneur.2025.1633214
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Henan Provincial Science and Technology Research Project