Bronchial thermoplasty reduces ventilation heterogeneity measured by phase-resolved functional lung magnetic resonance imaging in severe asthma
Clinical benefits post BT are accompanied by a reduction in ventilation heterogeneity that are undetected by lung function test. These findings provide valuable insights into the mechanisms of action of BT and highlight the complementary role of functional lung imaging in the study of pulmonary diseases for which traditional lung function tests may be insensitive at detecting therapeutic response.
Authors
- David Langton (ORCID: https://orcid.org/0000-0002-6098-1766)
- Bruce Thompson (ORCID: https://orcid.org/0000-0002-5885-0652)
- Peter B. Noble (ORCID: https://orcid.org/0000-0001-9028-7751)
- Chuan T. Foo (ORCID: https://orcid.org/0000-0003-1497-9830)
- Graham M. Donovan (ORCID: https://orcid.org/0000-0001-5903-5484)
- Francis Thien (ORCID: https://orcid.org/0000-0003-0925-6566)
Institutions
- University of Auckland (NZ)
- The University of Melbourne (AU)
- The University of Western Australia (AU)
- Eastern Health (AU)
- Peninsula Health (AU)
- Monash Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1186/s12931-025-03372-w
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Imaging Facility
- Monash University
- Medical Research Council
- National Health and Medical Research Council