Optimizing whole-body MRI for early cancer detection in Li-Fraumeni syndrome: a prospective bicentric study
Question Annual whole-body MRI (WB-MRI) is recommended for early cancer detection for individuals with Li-Fraumeni syndrome (LFS), but a standardized sequence protocol has yet to be established. Findings The combination of cranial FLAIR, whole-body HASTE, and whole-body DWI in the axial plane enabled visualization of all newly developed malignant lesions in our study cohort. Clinical relevance A shortened, standardized WB-MRI protocol enables efficient, sensitive early cancer detection in individuals with LFS, minimizing patient burden by reducing examination time and contrast agent use. This approach may improve surveillance participation while enhancing comparability across centers.
Authors
- Theresa Mokry (ORCID: https://orcid.org/0000-0002-5997-5254)
- Felix Tobias Kurz (ORCID: https://orcid.org/0000-0001-7616-7147)
- Sarah Schott (ORCID: https://orcid.org/0000-0002-1714-1147)
- Robert Hog (ORCID: https://orcid.org/0000-0002-8842-7601)
- Sebastian Bickelhaupt (ORCID: https://orcid.org/0000-0003-1043-4462)
- Diane Miriam Renz (ORCID: https://orcid.org/0000-0002-3702-356X)
- Tristan Anselm Kuder (ORCID: https://orcid.org/0000-0001-6439-8124)
- Christian P. Kratz (ORCID: https://orcid.org/0000-0003-4120-5873)
- Tawfik Moher Alsady (ORCID: https://orcid.org/0000-0002-0779-0688)
- Thomas Hielscher (ORCID: https://orcid.org/0000-0003-1277-310X)
- Myriam Keymling (ORCID: https://orcid.org/0000-0002-4447-5636)
- Heinz-Peter Schlemmer
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Heidelberg (DE)
- Medizinische Hochschule Hannover (DE)
- Universitätsklinikum Erlangen (DE)
- University Hospital of Geneva (CH)
Publication Details
- Journal
- European Radiology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1007/s00330-025-11880-y
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Deutsches Krebsforschungszentrum
- Bundesministerium für Bildung und Forschung
- Medizinischen Hochschule Hannover
- Hôpitaux Universitaires de Genève
- Universitätsklinikum Heidelberg