Severe chronic UTI sustained by clinically undetected intracellular <i>Escherichia coli</i> in a pediatric patient
This is the first report demonstrating long-term undetected IBC in a severely symptomatic child with chronic UTI. It underscores the need to learn more about intracellular bacteria and urinary tract biofilms that are protected from antibiotics and host immunity. IBC reservoirs seem to drive bladder wall inflammation, exacerbating clinical symptoms and increasing the risk of long-term adverse sequelae.
Authors
- Naveen Wijekoon (ORCID: https://orcid.org/0000-0002-7762-7579)
- Slade O. Jensen (ORCID: https://orcid.org/0000-0003-4489-589X)
- Neftali Flores‐Rodriguez (ORCID: https://orcid.org/0000-0001-6345-5609)
- Aniruddh Deshpande (ORCID: https://orcid.org/0000-0001-7303-9131)
- Ben J. Marais (ORCID: https://orcid.org/0000-0003-3404-2690)
- Jim Manos (ORCID: https://orcid.org/0000-0002-5765-1563)
- Bill Söderström (ORCID: https://orcid.org/0000-0001-9266-5322)
- Kate H. Moore (ORCID: https://orcid.org/0000-0001-6947-9839)
- Greg Whiteley (ORCID: https://orcid.org/0000-0001-7830-1725)
- Arthika Manoharan (ORCID: https://orcid.org/0009-0002-7186-6971)
- Theerthankar Das Ashishkumar
Institutions
- The University of Sydney (AU)
- Taronga Conservation Society Australia (AU)
- Australian Institute of Business (AU)
- Children's Hospital at Westmead (AU)
- Whiteley Clinic (GB)
- St George Hospital (AU)
- Ingham Institute (AU)
- St. George Hospital (IN)
- Institute of Infection and Immunity (CA)
- University of Newcastle Australia (AU)
- Newcastle University (GB)
Publication Details
- Journal
- ASM Case Reports
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1128/asmcr.00077-25
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00