CGF-Conditioned Medium Modulates Astrocytic Differentiation and Invasiveness in U87MG Glioblastoma Cells
Our findings demonstrate that CGF-CM modulates the phenotypic plasticity of U87MG cells and promotes differentiation toward an astroglial-like profile. These results provide a basis for future studies on the modulation of GBM aggressiveness using bioactive autologous derivatives.
Authors
- Laura Giannotti (ORCID: https://orcid.org/0000-0002-9597-3862)
- Benedetta Di Chiara Stanca (ORCID: https://orcid.org/0000-0002-3073-9338)
- Luciano Abbruzzese (ORCID: https://orcid.org/0000-0003-2101-0817)
- Luisa Siculella (ORCID: https://orcid.org/0000-0002-6890-3674)
- Eleonora Stanca (ORCID: https://orcid.org/0000-0002-0087-1231)
- Fabrizio Damiano (ORCID: https://orcid.org/0000-0001-7828-9519)
- Franco Ferrante (ORCID: https://orcid.org/0000-0001-6392-0048)
- Francesco Spedicato (ORCID: https://orcid.org/0000-0001-5274-3939)
- Christian Demitri (ORCID: https://orcid.org/0000-0002-1145-6674)
- Andrea Palermo (ORCID: https://orcid.org/0000-0002-3288-490X)
- Maria Antonietta De Sangro
Institutions
- University of Salento (IT)
- Innovation Engineering (Italy) (IT)
- Ospedale Vito Fazzi (IT)
- National Research Council (IT)
- Institute of Polymers, Composites and Biomaterials (IT)
Publication Details
- Journal
- Biology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.3390/biology14101461
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00