Baseline use of aspirin or statins with oral estrogen and progestogens to prevent incident arterial or venous thrombotic events: a secondary analysis of the Women’s Health Initiative trial

In this secondary randomized clinical trial analysis, neither statins nor aspirin significantly modified effects of oral HT on key arterial or venous thrombotic outcomes at 2 or 5 years. Results, however, may be underpowered given low baseline exposure prevalence for both statins and aspirin.

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Publication Details

Journal
Menopause The Journal of The North American Menopause Society
Published
2025-10-21
DOI
https://doi.org/10.1097/gme.0000000000002647
Citations
1
Primary Topic
Menopause: Health Impacts and Treatments
Type
article
Field-Weighted Citation Impact
1.29
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article

Baseline use of aspirin or statins with oral estrogen and progestogens to prevent incident arterial or venous thrombotic events: a secondary analysis of the Women’s Health Initiative trial

Aladdin H. Shadyab, Laura B. Harrington, Aaron K. Aragaki, Chrisandra Shufelt et al.
1 citations
Menopause The Journal of The North American Menopause Society
Menopause: Health Impacts and Treatments
1.29
article

Baseline use of aspirin or statins with oral estrogen and progestogens to prevent incident arterial or venous thrombotic events: a secondary analysis of the Women’s Health Initiative trial

Aladdin H. Shadyab, Laura B. Harrington, Aaron K. Aragaki, Chrisandra Shufelt, John W. Davis, Robert A. Wild, Gretchen Wells, Lisa Warsinger Martin, Jacques E. Rossouw, JoAnn E. Manson, Peter F. Schnatz
article en
1 citations

Abstract

In this secondary randomized clinical trial analysis, neither statins nor aspirin significantly modified effects of oral HT on key arterial or venous thrombotic outcomes at 2 or 5 years. Results, however, may be underpowered given low baseline exposure prevalence for both statins and aspirin.

Menopause The Journal of The North American Menopause SocietyVol. 33(2)
Brigham and Women's Hospital (US), Barnes-Jewish Hospital (US), Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), Kaiser Permanente (US), Kaiser Permanente Washington Health Research Institute (US), George Washington University (US), University of Washington (US), Jacksonville College (US), University of Alabama at Birmingham (US), University of California San Diego (US), Fred Hutch Cancer Center (US), Jewish Hospital (US), National Heart, Lung, and Blood Institute (US), Mayo Clinic in Arizona (US), Human Longevity (United States) (US), Mayo Clinic in Florida (US), University of Oklahoma Health Sciences Center (US), Drexel University (US)
Openalex Percentile: Top 14%
Menopause: Health Impacts and Treatments
1.29
DOISourceOpenAlex
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