Fabrication and Dielectric Characterization of Stable Oil in Gelatin Breast Tissue Phantoms for Microwave Biomedical Imaging

Breast tissue-mimicking phantoms are essential tools for validating microwave imaging systems designed for early breast cancer detection. In this work, we report the fabrication and comprehensive characterization of oil-in-gelatin phantoms emulating normal, benign, and malignant breast tissues. The phantoms were manufactured with controlled mixtures of kerosene, safflower oil, and gelatin, and their dielectric properties were experimentally evaluated using a free-space transmission method with a Vector Network Analyzer across the 100 MHz-10 GHz range. Results demonstrated significant contrast in permittivity and conductivity among the different tissue types, consistent with values reported in the literature. Long-term stability was confirmed for up to six months under controlled storage. Additional structural and thermal characterization was performed using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA), providing insight into molecular composition and thermal response. The proposed method enables reproducible, low-cost, and stable phantom fabrication, offering reliable tissue models to support experimental validation and optimization of microwave-based breast cancer detection systems.

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Publication Details

Journal
Micromachines
Published
2025-10-21
DOI
https://doi.org/10.3390/mi16101189
Primary Topic
Microwave Imaging and Scattering Analysis
Type
article
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article

Fabrication and Dielectric Characterization of Stable Oil in Gelatin Breast Tissue Phantoms for Microwave Biomedical Imaging

Armando Aguilar-Meléndez, Jorge Alberto Chagoya-Ramírez, Javier Calderón-Sánchez, Víctor Velázquez-Martínez et al.
Micromachines
Microwave Imaging and Scattering Analysis
article

Fabrication and Dielectric Characterization of Stable Oil in Gelatin Breast Tissue Phantoms for Microwave Biomedical Imaging

Armando Aguilar-Meléndez, Jorge Alberto Chagoya-Ramírez, Javier Calderón-Sánchez, Víctor Velázquez-Martínez, C. Calderón-Ramón, Héctor Daniel López-Calderón, J. Martínez-Castillo, J.R. Laguna-Camacho, Benoit Roger-Fouconnier, Enrique López-Calderón
article en

Abstract

Breast tissue-mimicking phantoms are essential tools for validating microwave imaging systems designed for early breast cancer detection. In this work, we report the fabrication and comprehensive characterization of oil-in-gelatin phantoms emulating normal, benign, and malignant breast tissues. The phantoms were manufactured with controlled mixtures of kerosene, safflower oil, and gelatin, and their dielectric properties were experimentally evaluated using a free-space transmission method with a Vector Network Analyzer across the 100 MHz-10 GHz range. Results demonstrated significant contrast in permittivity and conductivity among the different tissue types, consistent with values reported in the literature. Long-term stability was confirmed for up to six months under controlled storage. Additional structural and thermal characterization was performed using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA), providing insight into molecular composition and thermal response. The proposed method enables reproducible, low-cost, and stable phantom fabrication, offering reliable tissue models to support experimental validation and optimization of microwave-based breast cancer detection systems.

MicromachinesVol. 16(10)
Universidad Veracruzana (MX)
Openalex Percentile: Top 71%
Microwave Imaging and Scattering Analysis
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