Retrospective Cohort Study Comparing Outcomes and High-Risk Factors of Patients Presenting with Necrotizing Soft Tissue Infections in Far North Queensland—20 Years of Experience

213 patients were identified. There was a 14% mortality rate, and common comorbidities were diabetes, smoking, high BMI and high ethanol use. Patients were likely to present with vital signs within the normal range and high inflammatory markers. Of the patients, 51% identified as First Nations, an incidence rate 88 times higher than all other ethnicities put together. First Nations patients were younger (51.78 vs. 55.74 years, <i>p</i> = 0.02), had higher rates of diabetes (86% vs. 34%, <i>p</i> ≤ 0.001), shorter times spent in ICU (6.77 days vs. 10.1 days, <i>p</i> = 0.03), higher average time to theatre (57.7 h vs. 35.3 h, <i>p</i> = 0.03) but a comparable mortality rate (13.9% vs. 13.3%, <i>p</i> ≥ 0.99) Conclusions: This study helps us to better understand NSTI in the Australian setting as a basis for further research.