Hesperidin protects against sodium fluoride-induced molecular, stereological, and behavioral alterations in the rat cerebellum
Prolonged NaF exposure is linked to cerebellar structural alterations and motor deficits, likely mediated by oxidative stress, apoptosis, and disrupted neurotrophic signaling. In this experimental model, appeared to mitigate these effects by enhancing antioxidant defenses and supporting neuroprotective mechanisms, suggesting its potential to preserve cerebellar structure and function under fluoride-induced toxicity.
Authors
- Sina Mojaverrostami (ORCID: https://orcid.org/0000-0001-5479-1168)
- Parinaz Javanbakht (ORCID: https://orcid.org/0000-0002-6680-4613)
- Shiva Amirizadeh
- Iraj Ragerdi Kashani (ORCID: https://orcid.org/0000-0003-3842-7950)
- Maedeh Hashemi (ORCID: https://orcid.org/0000-0003-3203-9842)
- Reza Asadi-Golshan (ORCID: https://orcid.org/0000-0003-1901-7171)
- Afshin Talebinasab
- Maryam Shabani (ORCID: https://orcid.org/0000-0002-5813-0655)
- Leila Keshavarz (ORCID: https://orcid.org/0000-0002-3649-8598)
Institutions
- Shiraz University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Nutritional Neuroscience
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1080/1028415x.2025.2575810
- Citations
- 1
- Primary Topic
- Fluoride Effects and Removal
- Type
- article
- Field-Weighted Citation Impact
- 0.82