Palladium-Catalyzed Double Carbonylation for the Synthesis of Benzofuranone-Linked Ynones and Amides
An unprecedented palladium-catalyzed double carbonylation for the construction of benzofuranone-linked ynones and amides has been developed. This double carbonylation reaction features operational simplicity, a broad substrate scope, good functional group compatibility, easy scale-up, as well as versatile transformations. The application of double carbonylation for the synthesis of other biologically and synthetically useful carbonyl-containing molecules is underway in our lab.
Authors
- Xiaoqin Pei
- Xumeng Wang
- Jiang Shang (ORCID: https://orcid.org/0000-0001-8438-597X)
- D. M. Zhang
- Weiming Hu (ORCID: https://orcid.org/0000-0002-0157-1089)
- Huayou Hu (ORCID: https://orcid.org/0000-0003-4795-0866)
- Xiulian Zhang (ORCID: https://orcid.org/0000-0003-1418-2864)
- Fujun Yin
- Wenting Guo (ORCID: https://orcid.org/0000-0003-0847-4318)
Institutions
- Dimensional Imaging (United Kingdom) (GB)
- Advanced Materials and Technologies (Slovenia) (SI)
- Huaiyin Normal University (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1021/acs.joc.5c02032
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00