Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes: A Swedish population-based children-of-monozygotic twins study
Although the intergenerational transmission between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes appeared partially attributable to unmeasured familial (environmental or genetic) factors that influenced both generations, there was also evidence of either nonshared factors or direct causal effects. If the latter, then treating parental psychiatric conditions would reduce the risk of psychiatric vulnerability in offspring.
Authors
- Zheng Chang (ORCID: https://orcid.org/0000-0002-8087-1417)
- Isabell Brikell (ORCID: https://orcid.org/0000-0002-3800-6665)
- Henrik Larsson (ORCID: https://orcid.org/0000-0002-6851-3297)
- Paul Lichtenstein (ORCID: https://orcid.org/0000-0003-3037-5287)
- Mengping Zhou (ORCID: https://orcid.org/0000-0002-6117-0690)
- Ralf Kuja‐Halkola (ORCID: https://orcid.org/0000-0002-3765-2067)
- Erik Pettersson (ORCID: https://orcid.org/0000-0003-0149-9002)
- Brian Matthew D'Onofrio (ORCID: https://orcid.org/0000-0002-5248-7434)
- Mikael Landén
Institutions
- Aarhus University (DK)
- Örebro University (SE)
- Karolinska Institutet (SE)
- Indiana University Bloomington (US)
- University of Bergen (NO)
- University of Gothenburg (SE)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1371/journal.pmed.1004784
- Citations
- 1
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 1.88