A Novel Zinc(II) Complex for Sonodynamic Therapy Induces Pyroptosis of Breast Cancer Cells and Enhances Anti‐Tumor Immune Response
Zinc(II) complexes have emerged as promising antitumor agents due to their favorable biosafety and biocompatibility, and demonstrated effectiveness in photodynamic therapy (PDT). However, their therapeutic potential is limited by the poor tissue penetration of PDT agents. Herein, a novel zinc(II) complex designed for sonodynamic therapy (SDT), capable of producing substantial amounts of singlet oxygen upon ultrasonic activation, is introduced. This sonosensitizer effectively induces pyroptosis in breast cancer cells, significantly promoting the antitumor immune response. This work represents the first exploration of zinc(II) complexes in SDT, establishing a new avenue for enhanced therapeutic outcomes against breast cancer.
Authors
- Kun Shang
- Hanchen Zhang (ORCID: https://orcid.org/0000-0003-0498-429X)
- Haihua Xiao (ORCID: https://orcid.org/0000-0001-8159-8187)
- Dongsheng Tang (ORCID: https://orcid.org/0000-0001-5379-8472)
- Kong Wai Tan (ORCID: https://orcid.org/0000-0001-6863-8367)
- Xiaojun Wang (ORCID: https://orcid.org/0000-0003-2432-511X)
- Sijie Wen
- Zheng Cao
- Lingpu Zhang (ORCID: https://orcid.org/0009-0003-1826-7969)
Institutions
- University of California, Los Angeles (US)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- University of Malaya (MY)
- Beijing National Laboratory for Molecular Sciences (CN)
- Peking University People's Hospital (CN)
- Institute of Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1002/advs.202508155
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- National Natural Science Foundation of China