Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation
These findings identify FABP4<sup>+</sup> ECs as key mediators in the connection between periodontitis and PADs. The study provides new insights into the systemic effects of periodontitis and offers a basis for developing preventive and therapeutic strategies for periodontitis-associated vascular diseases.
Authors
- Kun Fang (ORCID: https://orcid.org/0000-0003-3922-4434)
- Shouzheng Cheng (ORCID: https://orcid.org/0009-0005-4659-5382)
- Bing Shi (ORCID: https://orcid.org/0000-0001-5100-2485)
- Hanyao Huang (ORCID: https://orcid.org/0000-0002-6805-0157)
- Chengxin Weng
- Леи Жао (ORCID: https://orcid.org/0000-0002-9612-3114)
- Renjie Yang
- Yafei Wu (ORCID: https://orcid.org/0000-0003-3667-7091)
- Xuanzhi Zhu (ORCID: https://orcid.org/0000-0002-7291-5045)
- Kam W. Leong (ORCID: https://orcid.org/0000-0002-8133-4955)
- Jinting Ge (ORCID: https://orcid.org/0000-0003-0952-5850)
- Jiali Chen (ORCID: https://orcid.org/0000-0001-7376-3322)
- Dan Shao
Institutions
- Sichuan University (CN)
- Columbia University Irving Medical Center (US)
- West China Hospital of Sichuan University (CN)
- Cancer Genetics (United States) (US)
- Columbia University (US)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1111/jcpe.70055
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Sichuan Provincial Postdoctoral Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan University
- Health Commission of Sichuan Province
- Sichuan Province Science and Technology Support Program