Long‐term remission in gout: Challenges and future opportunities

Abstract Among rheumatic diseases, the prevalence of gout is increasing with population growth and aging. While hyperuricemia remains the major risk factor, gout is now recognized as a curable disease. Several recommendations have been proposed to achieve treatment goals; however, only a small proportion of patients receive adequate management and achieve target serum urate levels. Without proper management, patients often experience gout flares, which can be triggered by multiple risk factors. Recently, tools and criteria have been developed to assess disease activity and define clinical remission in gout. Therefore, this review aims to highlight factors that precipitate gout flares, summarize evidence supporting complete disease control, outline principles and strategies for long‐term management, and provide potential future perspectives.

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Publication Details

Journal
Rheumatology & autoimmunity
Published
2025-10-21
DOI
https://doi.org/10.1002/rai2.70027
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
Field-Weighted Citation Impact
0.00
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article

Long‐term remission in gout: Challenges and future opportunities

Patapong Towiwat, Zhanguo Li
Rheumatology & autoimmunity
Gout, Hyperuricemia, Uric Acid
article

Long‐term remission in gout: Challenges and future opportunities

Patapong Towiwat, Zhanguo Li
article en

Abstract

Abstract Among rheumatic diseases, the prevalence of gout is increasing with population growth and aging. While hyperuricemia remains the major risk factor, gout is now recognized as a curable disease. Several recommendations have been proposed to achieve treatment goals; however, only a small proportion of patients receive adequate management and achieve target serum urate levels. Without proper management, patients often experience gout flares, which can be triggered by multiple risk factors. Recently, tools and criteria have been developed to assess disease activity and define clinical remission in gout. Therefore, this review aims to highlight factors that precipitate gout flares, summarize evidence supporting complete disease control, outline principles and strategies for long‐term management, and provide potential future perspectives.

Rheumatology & autoimmunityVol. 6(1)
Peking University (CN), Peking University People's Hospital (CN), Naresuan University (TH)
Openalex Percentile: Top 69%
Gout, Hyperuricemia, Uric Acid
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