Symptom‐Based Testosterone Therapy in Japanese Men With Late‐Onset Hypogonadism Syndrome: A Real‐World Single‐Arm Study Following the 2022 Guideline
Testosterone replacement therapy combined with daily phosphodiesterase-5 inhibitors is effective for late-onset hypogonadism-related symptoms, even in patients with normal testosterone levels. These findings support the revised Japanese guidelines, which promote a symptom-oriented treatment strategy alongside biochemical evaluation.
Authors
- Ichiya Honma
- Takashi Shimizu
- Musashi Tobe (ORCID: https://orcid.org/0000-0002-5504-2473)
- Keitarou Watanabe
- Megumi Hirobe
- Kazunori Haga (ORCID: https://orcid.org/0009-0001-7618-6783)
- Junji Ishizaki
- Keigo Akagashi
- Yoshikazu Sato (ORCID: https://orcid.org/0000-0002-2205-1357)
- Kosuke Uchida
- Hisao Nakajima
Institutions
- Keiyukai Sapporo Hospital (JP)
Publication Details
- Journal
- International Journal of Urology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1111/iju.70257
- Citations
- 1
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 1.29