Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers

This study provides compelling evidence that spectral signatures of abnormal brain activity commonly observed in humans can be recapitulated in larval zebrafish. These electrical events in zebrafish could serve as important biomarkers. These observations not only reinforce the value of zebrafish as an important preclinical animal model for epilepsy research but also suggest new avenues for deconstruction of pathological epileptic networks in an experimental setting.